Healthy Aging with Polyphenols

As children, when our grandmothers told us to “eat your fruits and vegetables” they weren’t trying to torture us with our least favorite foods (well, maybe they were!).  Our elders understood that plant food is inherently nutritious and essential for proper growth and development. Instinctually, we are guided toward foods and habits that help us survive and thrive.  Generations of humans have thrived on the full spectrum of essential nutrients and antioxidant compounds in fruits and vegetables, in fact, our ancestral diet had variability and a variety of nutrient-dense, fiber-rich, and unprocessed plant foods. There have been remarkable changes in human culture over the last 40,000 years, however, our nutritional needs have remained essentially the same.  Our genes are 99.9% the same as our pre-agricultural revolution ancestors.  The healthy compounds in fruits and vegetables that nourished generations of your family are the same compounds that you need today to experience optimal health.

The name “polyphenols” is a broad term for many different healthy compounds, including flavones, anthocyanins, catechins, curcuminoids, and phenolic acids. They are the natural compounds that give fruits, vegetables, rhizomes, roots, and flowering herbs their color and protect them from bacteria, insect damage, oxidative stresses, ionizing radiation, and other threats. In human diets, polyphenols act as anti-inflammatories, immune-boosters, and DNA-protectors—just to name a few of their attributes.

Ideally, our diets should include a lot of polyphenols with every meal, but unfortunately, our Standard American Diet (SAD) includes little if any polyphenols. Medical experts estimate that we need at least 1000 mg of polyphenols in our diets each day for optimal wellness. Today’s fruits and vegetables are developed with appearance, shelf life, and ease of shipping in mind, rather than nutritional value. And sometimes our diets just aren’t healthy.  I think that a supplemental regimen that includes consistent levels of standardized polyphenols is an excellent way to fill in any gaps that may be left behind by less-than-perfect diets.

Here’s a quick look at some of my favorite sources of polyphenols and why they are so important:

Curcumin from Turmeric

Curcumin, the key polyphenol component from the rhizome of the turmeric plant, is what gives curries a distinctive bright orange color. Curcumin has been clinically and scientifically studied.  While turmeric has been part of successful traditional Ayurvedic practice for generations, the absorption of curcumin has been a challenge. To begin with, there is only about two to five percent curcumin present in turmeric, so getting benefits from the spice form alone could be difficult. Secondly, curcumin is not readily absorbed in the digestive tract, so even standardized 95 percent extracts may not yield results. And adding black pepper extract (piperine) to increase bioavailability could increase the risk of adverse interactions with commonly prescribed medications. The clinically tested curcumin that I prefer is combined with turmeric essential oil for improved absorption—up to 700 percent—and better blood retention. This curcumin is so effective that it is the first choice among researchers for osteoarthritis, rheumatoid arthritis, Alzheimer’s, depression, and cancer. And in several of these studies, it either matches or outperforms conventional drugs.

Oligomeric Proanthocyanidins (OPCs) from French Grape Seed

Grape seed is especially known for preventing heart disease because it addresses many concerns: it protects blood vessel walls from free radical damage and prevents the dangerous oxidation of LDL cholesterol. In a randomized, double-blind placebo study, grape seed extract not only moderated blood pressure but also reduced feelings of stress. In scientific studies, it has been shown to strengthen the structure of joints and bones. In cancer research, OPCs from French grape seed extract has been found to shrink tumor cells and prevent tumor recurrence.  These OPCs, an especially powerful type of polyphenols, kill cancer stem cells—the “seeds” of tumors that conventional chemotherapy drugs can’t reach.


Propolis is used by bees to help build and maintain their hives. It is rich in compounds that have anti-bacterial and anti-viral actions that help preserve the health of the hive structure and the bees that live there. Properly filtered to remove waxes and other impurities, propolis is an incredibly effective source of flavonoids and phenolic acids: clinical studies show that propolis can reduce the duration and severity of ear infections and prevent them from recurring or developing into upper respiratory tract infections. It is also effective against antibiotic-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans, and Streptococcus pyogenes. Propolis also fights DNA damage that leads to cancerous tumors, liver disease, and other conditions. It boosts the production of natural anti-inflammatory components in the body and has been shown to improve memory, attention span, and concentration in elderly individuals.


Apples are excellent sources of a variety of polyphenols, including OPCs. In supplemental use, apple polyphenols are typically extracted from unripe apples, while they are still plentiful in the fruit. Apple polyphenols have been shown to improve physical endurance and reduce fatigue, reduce abdominal fat, and improve cholesterol levels. They also show impressive results for reducing allergy symptoms, including skin irritation and rashes, inflamed sinuses, and runny noses.

Green Tea

Green tea is already considered one of the world’s healthiest beverages, so much so that its polyphenols, called catechins, are frequently standardized and used in research. One green tea polyphenol, in particular, epigallocatechin gallate (EGCG), is often the focus of intensive study. In terms of healthy aging, green tea is a gold mine: it reduces the effects of photoaging in the skin due to sun exposure and UV radiation, increases collagen production in the skin, fosters better connections between the hemispheres of the brain, fights bacterial infections, and suppresses inflammatory factors that can lead to Alzheimer’s.

Polyphenols are nature’s Insurance Policy

There are so many things that polyphenols can do, it’s tough to narrow down the list. But I think you can see the value of these incredible nutrients. Physical vigor and stamina, mental focus and well-being, robust immune resistance, and cardiovascular strength are just a few of the ways they help us live with vitality and in an optimal state of excellent health. Much like a multivitamin and mineral formula, adding polyphenols to your regimen every day is one of the best forms of natural insurance that you can invest in.


Michael Chase, MS, NTP

Nutrition Science and Dietetics

DISCLAIMER: The information provided in this post is for educational purposes only, and should not be construed as personal medical advice or instruction. No action should be taken based solely on the contents of this information. Individuals should consult appropriate health professionals on any matter relating to their health and well-being. The statements made in this informational document have not been evaluated by the Food and Drug Administration. Any product discussed is not intended to diagnose, treat, cure or prevent any disease.

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